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Acta Cytol. 2006 May-Jun;50(3):309-11.

Performance of an imaging system vs. manual screening in the detection of squamous intraepithelial lesions of the uterine cervix.

Author information

1
Depatment of Pathology and New England Pathology Associates, Mery Medical Center, Springfield, Massachusetts 01104, USA. kathleen.dziura@sphs.com

Abstract

OBJECTIVE:

To compare the ThinPrep Imaging System (Cytyc Corp., Boxborough Massachusetts, U.S.A) to manual screening in the detection of cervical squamous epithelial lesion (SIL).

STUDY DESIGN:

A total of 27,525 manually screened ThinPrep Pap tests were compared with 27,725 imaged ThinPrep Pap tests for: (1) diagnostic rates of atypical squamous cells of undetermined significance; atypical squamous cells of undetermined significance, cannot rule out high grade SIL (ASC-H); low grade SIL and high grade SIL (HSIL); (2) ASC/SIL ratio; (3) high-risk HPV positivity for ASC; and (4) biopsy follow-up for ASC-H and HSIL.

RESULTS:

There were significant increases in the percentage of cytologic diagnoses in all categories with the imager. The ASC/SIL ratios of both groups were comparable. There was a significant decrease in HPV positivity in the imager group of ASC. Biopsy results confirmed a significant increase in the detection of HSIL in both the ASC-H and HSIL groups of the imaged cohort.

CONCLUSION:

The ThinPrep Imaging System is significantly better than manual screening in the detection of cervical SIL.

PMID:
16780026
DOI:
10.1159/000325959
[Indexed for MEDLINE]
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