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Clin Infect Dis. 2006 Jul 15;43(2):e19-22. Epub 2006 Jun 9.

Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.

Author information

1
National Hansen's Disease Programs, Louisiana State University, Baton Rouge, LA 70803, USA. dscoll1@lsu.edu

Abstract

Humanized monoclonal antibodies to tumor necrosis factor- alpha are valuable for the treatment of rheumatologic conditions, but they have been associated with the development of serious infections. We report the first 2 cases of leprosy developing after treatment with infliximab. After discontinuation of infliximab, both patients developed type 1 ("reversal") leprosy reactions.

PMID:
16779736
DOI:
10.1086/505222
[Indexed for MEDLINE]

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