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Haemostasis. 1991;21(1):5-9.

Substitution of factor XIII: a therapeutic approach to ulcerative colitis.

Author information

1
II. Medizinische Klinik und Poliklinik, Technischen Universität München, FRG.

Abstract

Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80.3%, respectively). Because of the lack of clinical improvement during conservative therapy, the patients were treated additionally with F XIII concentrate (Fibrogammin HS, Behring, FRG) for 10 days. The substitution resulted in an increase in F XIII activity (144.3%) and F XIII subunit A (238%) as well as in a marked improvement in symptoms.

PMID:
1677916
DOI:
10.1159/000216195
[Indexed for MEDLINE]

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