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Qualitative pharmacokinetic modeling of drugs.

Author information

1
Department of Biomedical and Health Informatics, University of Washington, USA.

Abstract

We hypothesize that a representation of drug-drug interactions (DDIs) based on physiologic, pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms will provide more accurate and useful information to clinicians than current approaches that simply tabulate and index pairwise interactions of drugs. This paper explores the strengths, weaknesses, and difficulties of modeling drug mechanisms and reports on our initial work designing and implementing a drug KB based on qualitative pharmacokinetic mechanisms.

PMID:
16779004
PMCID:
PMC1560821
[Indexed for MEDLINE]
Free PMC Article

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