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J Comput Assist Tomogr. 2006 May-Jun;30(3):525-34.

Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model.

Author information

1
Division of Hematology Oncology, Department of Pediatrics, University of Southern California and the Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA.

Abstract

OBJECTIVE:

This study evaluates the use of multimodal imaging to qualitatively and quantitatively measure tumor progression and bone resorption in a xenotransplanted tumor model of human neuroblastoma.

METHODS:

Human neuroblastoma cells expressing a luciferase reporter gene were injected into the femur of nu/nu mice. Tumor progression with and without zoledronic acid treatment was monitored using radiographs, D-luciferin-induced luminescence, micro-computer tomography (CT) and micro-magnetic resonance imaging (MRI).

RESULTS:

We observed a gradual increase in D-luciferin-based bioluminescence concomitant with detectable osteolytic lesions. Tumor growth was inhibited (P=0.003-0.07) with zoledronic acid treatment. Micro-CT analysis in vivo provided a method to quantify bone loss, and its prevention by zoledronic acid. High-resolution MRI images allowed the observation of tumor cells within the bone marrow cavity, as well as distant metastasis.

CONCLUSION:

Multimodal imaging allows to measure tumor growth and bone resorption simultaneously in vivo and also proved useful in the detection distant metastasis.

PMID:
16778634
[Indexed for MEDLINE]

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