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Cancer Res. 2006 Jun 15;66(12):5997-6001.

Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration.

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Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Mannheim, Germany and Division of Cellular Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.


Using IFN-gamma enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients.

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