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Cell. 2006 Jun 16;125(6):1036-8.

P-bodies react to stress and nonsense.

Author information

1
Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.

Abstract

P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress. Meanwhile, Sheth and Parker (2006) report that aberrant mRNAs are targeted to P-bodies to undergo rapid decay.

PMID:
16777595
DOI:
10.1016/j.cell.2006.06.003
[Indexed for MEDLINE]
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