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Neurobiol Dis. 2006 Sep;23(3):573-7. Epub 2006 Jun 14.

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons.

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1
Center for Biochemistry and Molecular Cell Biology, University of Göttingen, Humboldtallee 23, 37073 Göttingen, Germany.

Abstract

A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Abeta-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Abeta. We found that reduction of neuronal cholesterol by approximately 25% reduced the neuronal formation of insoluble Abeta without affecting the secretion of soluble Abeta. Moreover, we demonstrate that Abeta-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of Abeta.

PMID:
16777421
DOI:
10.1016/j.nbd.2006.04.015
[Indexed for MEDLINE]
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