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Med Sci Sports Exerc. 2006 Jun;38(6):1098-105.

Oxidative stress response to aerobic exercise: comparison of antioxidant supplements.

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Department of Health and Sport Sciences, University of Memphis, Memphis, TN 38512, USA.



To compare the effects of two antioxidant formulas on biomarkers of oxidative stress before and after aerobic exercise.


Aerobically trained men (N=25) and women (N=23) were assigned to one of three treatments: 400 IU of vitamin E+1 g of vitamin C (V; N=15), a fruit and vegetable juice powder concentrate (FV; N=16), or a placebo (P; N=17). Subjects ran for 30 min at 80% VO(2 max) before, after 2 wk of supplementation, and after a 1-wk washout period. Blood samples were taken before and immediately after exercise and analyzed for protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and vitamins C and E.


The V treatment increased plasma vitamin C and E after 2 wk (P <or= 0.05), with no change in the FV or P. Postexercise PC values were elevated for all treatments after all exercise bouts (P< 0.0001). Both V and FV attenuated the exercise-induced increase in PC after 2 wk of supplementation (V=21%, FV=17%), and after the 1-wk washout (V=13%, FV=6%) compared with P (P<0.05), with no differences between V and FV. MDA was unaffected by exercise and treatment. A treatment main effect for 8-OHdG was noted, with values for V lower than for FV and P (4.5+/-2.5, 5.5+/-2.7, and 6.0+/-2.5 ng.mL, respectively; P=0.0002). No exercise session or time main effect was noted for 8-OHdG, suggesting that the lower mean value for the V treatment group was not a result of the supplementation.


These data suggest that V and FV supplementation for 2 wk can attenuate the rise in PC after 30 min of aerobic exercise, even after a 1-wk washout, without an impact on plasma MDA or 8-OHdG.

[Indexed for MEDLINE]

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