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Tissue Antigens. 2006 Jul;68(1):82-6.

Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.

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1
Centre for Integrated Genomic Medical Research, University of Manchester, Oxford Road, Manchester M13 9PT, UK. lorna.kennedy@mahchester.ac.uk

Abstract

Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.

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