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World J Gastroenterol. 2006 Jun 21;12(23):3695-706.

Platelet-activating factor in liver injury: a relational scope.

Author information

1
Department of Forensic Medicine and Toxicology, University of Athens Medical School, Athens, Greece.

Abstract

The hepatocyte, the main cellular component of the liver, exhibits variable susceptibility to different types of injury induced by endogenous or exogenous factors. Hepatocellular dysfunction or death and regeneration are dependent upon the complicated interactions between numerous biologically active molecules. Platelet-activating factor (PAF) seems to play a pivotal role as the key mediator of liver injury in the clinical and experimental setting, as implied by the beneficial effects of its receptor antagonists. A comprehensive up-to-date overview of the specific functional and regulatory properties of PAF in conditions associated with liver injury is attempted in this review.

PMID:
16773686
PMCID:
PMC4087462
DOI:
10.3748/wjg.v12.i23.3695
[Indexed for MEDLINE]
Free PMC Article

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