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Med Microbiol Immunol. 2007 Mar;196(1):1-10. Epub 2006 Jun 14.

Streptococcus agalactiae CAMP factor binds to GPI-anchored proteins.

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Department of Chemistry, University of Waterloo, N2L 3G1 Waterloo, ON, Canada.


CAMP factor (protein B) is a pore-forming protein secreted by Streptococcus agalactiae. It causes lysis of sheep red blood cells when these have been sensitized with staphylococcal sphingomyelinase. We here show that CAMP factor binds to GPI-anchored proteins, and that this interaction involves the carbohydrate core of the GPI-anchor. Enzymatic cleavage of GPI-anchors with phosphatidylinositol-specific phospholipase C strongly reduces the sensitivity of erythrocytes to CAMP factor. Incorporation of alkaline phosphatase, a model GPI-anchored protein, into liposome membranes renders the latter susceptible to permeabilization by CAMP factor. GPI-anchored proteins therefore function as cellular receptors for CAMP factor.

[Indexed for MEDLINE]

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