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Antioxid Redox Signal. 2006 May-Jun;8(5-6):753-62.

The many faces of glutathione in bacteria.

Author information

1
Department of Chemical Engineering, Institute for Cell and Molecular Biology, University of Texas, Austin, 78712-0231, USA.

Abstract

Glutathione is one of the most abundant thiols present in cyanobacteria and proteobacteria, and in all mitochondria or chloroplast-bearing eukaryotes. In bacteria, in addition to its key role in maintaining the proper oxidation state of protein thiols, glutathione also serves a key function in protecting the cell from the action of low pH, chlorine compounds, and oxidative and osmotic stresses. Moreover, glutathione has emerged as a posttranslational regulator of protein function under conditions of oxidative stress, by the direct modification of proteins via glutathionylation. This review summarizes the biosynthesis and function of glutathione in bacteria from physiological and biotechnological standpoints.

PMID:
16771667
DOI:
10.1089/ars.2006.8.753
[Indexed for MEDLINE]

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