Abstract
A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg x L(-1) and 5-80 mg x L(-1), respectively).
MeSH terms
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Amino Acid Sequence
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Animals
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Animals, Newborn
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Cell Proliferation / drug effects*
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DNA / biosynthesis
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Deer / metabolism*
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Dose-Response Relationship, Drug
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Epidermal Cells
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Epidermis / drug effects*
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Epidermis / metabolism
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Mice
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Molecular Sequence Data
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Molecular Weight
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NIH 3T3 Cells
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Peptides / chemistry
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Peptides / isolation & purification
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Peptides / pharmacology*
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Rats
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Rats, Wistar
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Sequence Analysis, Protein
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization