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Behav Brain Res. 2006 Sep 15;172(1):173-8. Epub 2006 Jun 12.

d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference.

Author information

1
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP-A-244, 7141 Sherbrooke Street West, Montreal, Que., Canada H4B 1R6.

Abstract

d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction.

PMID:
16769132
DOI:
10.1016/j.bbr.2006.05.012
[Indexed for MEDLINE]

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