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Phytochemistry. 2006 Jul;67(13):1326-30.

neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities.

Author information

1
School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China. daishengjun_9@hotmail.com

Abstract

Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.

PMID:
16769097
DOI:
10.1016/j.phytochem.2006.04.024
[Indexed for MEDLINE]

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