Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2006 Dec;195(6):1623-8. Epub 2006 Jun 12.

Alpha-fetoprotein detection of neural tube defects and the impact of standard ultrasound.

Author information

1
Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, TX TX 75235-9032, USA. jodi.dashe@utsouthwestern.edu

Abstract

OBJECTIVE:

The purpose of this study was to evaluate neural tube defect (NTD) detection according to whether serum alpha-fetoprotein (AFP) screening or standard ultrasound are performed.

STUDY DESIGN:

Prenatal and neonatal datasets were reviewed to identify pregnancies with NTDs from 1 institution between January 2000 and December 2003. AFP screening was offered < 21 weeks and considered elevated if > or = 2.50 multiples of the median. Standard ultrasound was performed for specific indications in low-risk pregnancies.

RESULTS:

There were 66 NTDs, 1 per 950 deliveries. AFP sensitivity was 65%. If the gestational age used for AFP calculation was confirmed with ultrasound, sensitivity improved to 86%. The sensitivity of standard ultrasound was 100%, P < .001 compared with AFP screening. NTDs detected with standard ultrasound were identified later in gestation, as examinations were performed for other indications.

CONCLUSION:

Standard ultrasound improved NTD detection over AFP screening alone, by improving AFP test sensitivity and identifying NTDs in low-risk pregnancies.

PMID:
16769022
DOI:
10.1016/j.ajog.2006.03.097
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center