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Psychopharmacology (Berl). 2006 Jul;187(1):56-9. Epub 2006 Apr 22.

Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation.

Author information

1
Department of Psychiatry, University of Dresden, Fetscherstr. 74, 01099 Dresden, Germany. undine.lang@gmx.de

Abstract

BACKGROUND:

Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression.

METHODS:

In this study, we report the impact of these stimulation techniques on serum concentrations of brain-derived neurotrophic factor (BDNF) in treatment-resistant patients with a diagnosis of major depression.

RESULTS:

We found no changes of BDNF serum concentrations and no association of neurotrophin concentrations in serum with clinical parameters in our sample.

CONCLUSION:

Our preliminary results suggest that brain stimulation techniques-in contrast to several antidepressant medications-do not change BDNF serum concentrations.

PMID:
16767416
DOI:
10.1007/s00213-006-0399-y
[Indexed for MEDLINE]

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