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Trends Endocrinol Metab. 2006 Jul;17(5):205-15.

Expanding role of AMPK in endocrinology.

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Department of Endocrinology, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, London, EC1M 6BQ, UK.


Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome.

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