Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Neurol. 2006 Jun;34(6):459-63.

Translational stroke research in the developing brain.

Author information

  • 1Department of Neurology, University of California San Francisco, San Francisco, California 94143-0663, USA. zinaida@atsa.ucsf.edu

Abstract

Preclinical animal models can help guide the development of clinical pediatric and newborn stroke trials. Data obtained using currently available models of hypoxia-ischemia and focal stroke have demonstrated the need for age-appropriate models. There are age-related differences in susceptibility of the immature brain to oxidative stress and inflammation, as well as in the rate and degree of apoptotic neuronal death. These issues need to be carefully addressed in designing future clinical trials.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center