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Semin Cell Dev Biol. 2006 Apr;17(2):185-93. Epub 2006 Apr 18.

Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues.

Author information

1
Department of Physiology and Developmental Biology, 355 WIDB, Brigham Young University, Provo, UT 84602, USA. jeff_barrow@byu.edu

Abstract

Embryonic patterning has traditionally been viewed as the establishment of spatially significant gene expression in response to secreted signals. Recent work has highlighted the role of the Wnt/planar cell polarity (PCP) pathway in patterning tissues. Rather than establishing characteristic arrays of gene expression, however, this pathway functions to institute uniform polarity of cells within a tissue. Cells thus polarized can undergo directed migrations, cell divisions, etc., which are essential for normal morphogenesis. In this review, I will highlight the similarities between mechanisms that establish patterns of polarity between Drosophila and vertebrates. Further, I will discuss recent advances with regard to Wnt/PCP signaling in vertebrates.

PMID:
16765615
DOI:
10.1016/j.semcdb.2006.04.002
[Indexed for MEDLINE]

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