Send to

Choose Destination
Semin Cell Dev Biol. 2006 Apr;17(2):185-93. Epub 2006 Apr 18.

Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues.

Author information

Department of Physiology and Developmental Biology, 355 WIDB, Brigham Young University, Provo, UT 84602, USA.


Embryonic patterning has traditionally been viewed as the establishment of spatially significant gene expression in response to secreted signals. Recent work has highlighted the role of the Wnt/planar cell polarity (PCP) pathway in patterning tissues. Rather than establishing characteristic arrays of gene expression, however, this pathway functions to institute uniform polarity of cells within a tissue. Cells thus polarized can undergo directed migrations, cell divisions, etc., which are essential for normal morphogenesis. In this review, I will highlight the similarities between mechanisms that establish patterns of polarity between Drosophila and vertebrates. Further, I will discuss recent advances with regard to Wnt/PCP signaling in vertebrates.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center