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Org Biomol Chem. 2006 Jun 21;4(12):2337-47. Epub 2006 May 3.

Analysis of the reactions used for the preparation of drug candidate molecules.

Author information

1
GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Tonbridge, UK. john.s.carey@gsk.com

Abstract

The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.

PMID:
16763676
DOI:
10.1039/b602413k
[Indexed for MEDLINE]

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