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Vaccine. 2006 Jul 17;24(29-30):5755-61. Epub 2006 May 4.

Enhanced protective immunity against pneumococcal infection with PspA DNA and protein.

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Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States.


The effect of priming and boosting with pspA/EF5668 and purified recombinant PspA/EF5668 was examined. With this strategy CBA/N mice were protected against fatal challenge with Streptococcus pneumoniae EF5668. Anti-PspA antibody titers were elevated, and Western analysis with the immune serum demonstrated cross-reactivity with PspA from several different pneumococcal isolates, representing different PspA clades. Immune serum localized cross-reactive epitopes to the alpha-helical domain of PspA/Rx1 and PspA/EF5668. We demonstrated that DNA/protein prime-boost immunizations can enhance protective immunity against pneumococcal challenge.

[Indexed for MEDLINE]

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