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Bull Exp Biol Med. 2005 Nov;140(5):582-4.

Reactions between beta-casomorphins-7 and 5-HT2-serotonin receptors.

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Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow.


Radioreceptor analysis showed that human beta-casomorphin-7 displaced 3H-spiperone from 5-HT2-serotonin receptors of the rat cerebral frontal cortex: EC50 8 +/- 1 microM. Human and bovine beta-casomorphin-7 dose-dependently blocked serotonin-induced human platelet aggregation: IC50 5 +/- 1 and 20 +/- 4 microM, respectively. It was proved that beta-casomorphins-7 act as 5-HT2-serotonin receptor antagonists; one of the mechanisms of their biological effects is presumably associated with modulation of the serotoninergic system.

[Indexed for MEDLINE]

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