Format

Send to

Choose Destination
See comment in PubMed Commons below
Obes Surg. 2006 Jun;16(6):804-6.

Adipocyte size and liability to cell death.

Author information

1
Department of Biochemistry (U38/FCT), Faculty of Medicine, University of Porto, Portugal.

Abstract

Obesity constitutes a serious health problem. Inflammation, which has recently been shown to follow adipocyte death, is at the basis of a series of pathogenic complications of obesity. Here we demonstrate, through modelling using the finite element method, that the bigger the adipocyte, the more fragile it becomes to rupture when submitted to common physical forces. This indicates that adipocyte size is an important determinant of cell death. Interventions to prevent adipocyte hypertrophy may, therefore, help to reduce the risk associated with obesity.

PMID:
16756747
DOI:
10.1381/096089206777346600
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center