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J Am Chem Soc. 2006 Jun 14;128(23):7402-3.

High-resolution NMR spectroscopy of a GPCR in aligned bicelles.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0307, USA.

Abstract

Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.

PMID:
16756269
PMCID:
PMC3236030
DOI:
10.1021/ja0606632
[Indexed for MEDLINE]
Free PMC Article

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