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J Cardiovasc Magn Reson. 2006;8(3):469-74.

T2 fluctuations in ischemic and post-ischemic viable porcine myocardium in vivo.

Author information

1
Vascular Biology Laboratory, St. Michael's Hospital, Toronto, Canada. warren.foltz@sw.ca

Abstract

T2 relaxation can augment delayed-enhancement viability imaging because it is sensitive to tissue edema and microcirculatory oxygen state. We demonstrate the T2 'signatures' of sub-lethal ischemia and stunning in porcine myocardium perfused by the distal left anterior descending artery, by imaging during percutaneous balloon occlusion for 25 minutes and subsequent reperfusion (n = 9). Muscle displayed ischemic dysfunction and partial post-ischemic functional recovery (p < or = 0.0004), concommitant with an elevated post-ischemic T2 (deltaT2 = 27 +/- 18%, p = 0.005). TTC staining verified muscle viability. The T2 fluctuations may reflect hyperemia and tissue cellular edema in accord with the known pathophysiology of ischemic and post-ischemic yet viable muscle.

PMID:
16755833
DOI:
10.1080/10976640600572897
[Indexed for MEDLINE]

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