Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation

Am J Hematol. 2006 Jul;81(7):535-7. doi: 10.1002/ajh.20567.

Abstract

We report a case of severe hemorrhagic cystitis after allogeneic transplantation in association with high BK viral load. After failure of aggressive hydration, platelet and blood transfusions, continuous bladder irrigation, and tapering of the immune suppression, we instilled cidofovir into the bladder, which resulted in decreased BK viral load and significant clinical improvement. Our case suggests that local cidofovir therapy for viral hemorrhagic cystitis is effective and well tolerated with no observed side effects.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravesical
  • Adult
  • Antiviral Agents / administration & dosage*
  • Antiviral Agents / adverse effects
  • BK Virus
  • Cidofovir
  • Cystitis / etiology
  • Cystitis / therapy*
  • Cytosine / administration & dosage
  • Cytosine / adverse effects
  • Cytosine / analogs & derivatives*
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Humans
  • Male
  • Organophosphonates / administration & dosage*
  • Organophosphonates / adverse effects
  • Platelet Transfusion
  • Polyomavirus Infections / etiology
  • Polyomavirus Infections / therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Radiotherapy Dosage
  • Stem Cell Transplantation*
  • Transplantation, Homologous
  • Viral Load

Substances

  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir