Format

Send to

Choose Destination
Stat Med. 2007 Feb 28;26(5):965-74.

Misspecified regression model for the subdistribution hazard of a competing risk.

Author information

1
INSERM U717, Hopital Saint-Louis, Paris, France. aurelien.latouche@paris7.jussieu.fr

Abstract

We consider a competing risks setting, when evaluating the prognostic influence of an exposure on a specific cause of failure. Two main regression models are used in such analyses, the Cox cause-specific proportional hazards model and the subdistribution proportional hazards model. They are exemplified in a real data example focusing on relapse-free interval in acute leukaemia patients. We examine the properties of the estimator based on the latter model when the true model is the former. An explicit relationship between subdistribution hazards ratio and cause-specific hazards ratio is derived, assuming a flexible parametric distribution for latent failure times.

PMID:
16755533
DOI:
10.1002/sim.2600
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center