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Chem Pharm Bull (Tokyo). 2006 Jun;54(6):869-72.

Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.

Author information

1
School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.

Abstract

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.

PMID:
16755060
DOI:
10.1248/cpb.54.869
[Indexed for MEDLINE]
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