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Acta Paediatr. 2006 Jun;95(6):645-9.

Attention-deficit/hyperactivity disorder: a plausible mouse model?

Author information

1
URA CNRS Récepteur et Cognition, Institut Pasteur, Paris, France. granon@pasteur.fr

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and heterogeneous disorder, highly prevalent in children and characterized by three main components: inattention, lack of inhibitory control and hyperactivity. Epidemiological evidence reveals that ADHD is associated with nicotine exposure, mostly, with prenatal cigarette smoking. Mice deleted for the beta2-subunit gene of the neuronal nicotinic receptor are proposed as a simple and reliable animal model for ADHD.

CONCLUSION:

Nicotinic agonists targeting the alpha4beta2 nicotinic receptors alleviate ADHD symptoms and may possibly contribute to an efficient therapy of ADHD children.

PMID:
16754543
DOI:
10.1080/08035250600719747
[Indexed for MEDLINE]

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