Send to

Choose Destination
Nature. 1991 Jun 6;351(6326):485-8.

A novel class II MHC molecule with unusual tissue distribution.

Author information

Department of Immunology, Scrips Clinic and Research Foundation, La Jolla, California 92037.


The repertoire of mature class II-restricted T cells is generated through a complex process of selection whereby early T cells confront class II molecules in the thymus, especially on epithelial cells. Expression of class II molecules on such cells is prominent both in the cortex and in the medulla. We have identified a novel class II molecule, H-20, which is expressed only in epithelial cells of the thymic medulla and in B cells. The unusual tissue distribution and the nonpolymorphic nature of H-20 suggest that its function is different from that of classical class II molecules.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center