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Genetics. 2006 Aug;173(4):2407-10. Epub 2006 Jun 4.

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.

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1
Mount Sinai Hospital Research Institute, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. clapcote@mshri.on.ca

Abstract

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.

PMID:
16751659
PMCID:
PMC1569715
DOI:
10.1534/genetics.106.060749
[Indexed for MEDLINE]
Free PMC Article
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