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Cell. 2006 Jun 2;125(5):829-31.

TFIIIC boxes in the genome.

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  • 1Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.


In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a barrier throughout the genome.

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