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Ophthalmology. 2006 Jun;113(6):904-12.

A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children.

Author information

1
Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA. pedig@jaeb.org

Abstract

OBJECTIVE:

To compare 2 hours of daily patching (combined with 1 hour of concurrent near visual activities) with a control group of spectacle wear alone (if needed) for treatment of moderate to severe amblyopia in children 3 to 7 years old.

DESIGN:

Prospective randomized multicenter clinical trial (46 sites).

PARTICIPANTS:

One hundred eighty children 3 to 7 years old with best-corrected amblyopic-eye visual acuity (VA) of 20/40 to 20/400 associated with strabismus, anisometropia, or both who had worn optimal refractive correction (if needed) for at least 16 weeks or for 2 consecutive visits without improvement.

INTERVENTION:

Randomization either to 2 hours of daily patching with 1 hour of near visual activities or to spectacles alone (if needed). Patients were continued on the randomized treatment (or no treatment) until no further improvement was noted.

MAIN OUTCOME MEASURE:

Best-corrected VA in the amblyopic eye after 5 weeks.

RESULTS:

Improvement in VA of the amblyopic eye from baseline to 5 weeks averaged 1.1 lines in the patching group and 0.5 lines in the control group (P = 0.006), and improvement from baseline to best measured VA at any visit averaged 2.2 lines in the patching group and 1.3 lines in the control group (P<0.001).

CONCLUSION:

After a period of treatment with spectacles, 2 hours of daily patching combined with 1 hour of near visual activities modestly improves moderate to severe amblyopia in children 3 to 7 years old.

PMID:
16751033
PMCID:
PMC1609192
DOI:
10.1016/j.ophtha.2006.01.069
[Indexed for MEDLINE]
Free PMC Article

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