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Cytokine Growth Factor Rev. 2006 Aug;17(4):245-57. Epub 2006 Jun 5.

The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology.

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Department of Normal Human Morphology, University of Trieste, Via Manzoni 16, 34138 Trieste, Italy.


TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.

[Indexed for MEDLINE]

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