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Crit Rev Eukaryot Gene Expr. 2006;16(2):155-70.

Cellular genetics of host susceptibility and resistance to virus infection.

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Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA.


Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.

[Indexed for MEDLINE]

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