A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus

Diabetologia. 2006 Aug;49(8):1985-7. doi: 10.1007/s00125-006-0302-8. Epub 2006 Jun 2.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genetic Variation
  • Genotype
  • Homeodomain Proteins / chemistry
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism*
  • Humans
  • Insulin / genetics*
  • Male
  • Oligonucleotide Probes
  • Pedigree
  • Promoter Regions, Genetic*
  • Trans-Activators / chemistry
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism*

Substances

  • Homeodomain Proteins
  • Insulin
  • Oligonucleotide Probes
  • Trans-Activators
  • pancreatic and duodenal homeobox 1 protein