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Am J Psychiatry. 2006 Jun;163(6):1103-5.

Serotonin transporter polymorphisms and persistent, pervasive childhood aggression.

Author information

1
Division of Child and Adolescent Psychiatry, University of Toronto, and the Centre for Addiction and Mental Health, 250 College St., Toronto, Ont. Canada, M5T 1R8. Joe_Beitchman@camh.net

Abstract

OBJECTIVE:

The purpose of this study was to examine the potential association of the serotonin transporter (5-HTT) gene and childhood aggression by testing the 5-HTT variable-number-tandem-repeat and serotonin transporter promoter polymorphism (5-HTTLPR), including the recently discovered Lg allelic variant of 5-HTTLPR.

METHOD:

Clinically referred children displaying extreme aggression, with a minimum 2-year history, were genotyped for 5-HTTLPR (N=77) and 5-HTT variable-number-tandem-repeat (N=78). Analyses compared genotype frequencies of the aggressive children with healthy comparison subjects.

RESULTS:

The "low expressing" genotypic variants of the 5-HTTLPR polymorphism (S/S, Lg/S, Lg/Lg) were significantly associated with childhood aggression.

CONCLUSIONS:

This is the first study to report a significant association between the 5-HTTLPR gene and childhood aggression.

PMID:
16741214
DOI:
10.1176/ajp.2006.163.6.1103
[Indexed for MEDLINE]

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