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Science. 2006 Jun 2;312(5778):1381-5.

Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.

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  • 1Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Abstract

Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

PMID:
16741121
PMCID:
PMC2568993
DOI:
10.1126/science.1124981
[PubMed - indexed for MEDLINE]
Free PMC Article
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