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Exp Physiol. 2006 Sep;91(5):803-6. Epub 2006 Jun 1.

Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.

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Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.


Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits that functions as a master regulator of oxygen homeostasis. Oxygen-dependent hydroxylation of HIF-1alpha provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. Hypoxia-inducible factor 1 plays critical roles in development, physiology and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1alpha subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.

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