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Dev Cell. 2006 Jun;10(6):693-706.

Staying in shape with formins.

Author information

1
Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany. faix@bpc.mh-hannover.de

Abstract

Formins constitute a diverse protein family present in all eukaryotes examined. They are defined by the presence of a formin homology 2 (FH2) domain, which possesses intrinsic and conserved functions regulating cytoskeletal dynamics. Over the past few years, formins have become recognized as potent nucleators of linear actin filaments that control a large variety of cellular and morphogenetic functions. Here, we review the molecular principles of formin-induced cytoskeletal rearrangements and their consequences for a growing number of biological processes.

PMID:
16740473
DOI:
10.1016/j.devcel.2006.05.001
[Indexed for MEDLINE]
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