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Lancet. 1991 May 11;337(8750):1137-9.

Treatment of systemic vasculitis with pooled intravenous immunoglobulin.

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Department of Medicine, School of Clinical Medicine, University of Cambridge, UK.


The therapeutic effect of a course of high-dose, pooled, intravenous immunoglobulin (IVIg) on disease activity and circulating antineutrophil cytoplasm antibodies (ANCA) was investigated in 7 patients with systemic vasculitis. 5 had active disease despite conventional immunosuppression, and 2 had not received any treatment. All 7 had clinical improvement, which was sustained in 6 and transient in 1. The fall in ANCA concentrations to a mean of 51% of the pre-treatment values was maintained during follow-up. C-reactive protein concentration also dropped considerably. IVIg seemed to confer a useful therapeutic effect without adverse reaction.

[Indexed for MEDLINE]

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