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Biol Chem. 2006 May;387(5):485-97.

Protein aggregation in crowded environments.

Author information

1
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. jellis@bio.warwick.ac.uk

Abstract

The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.

PMID:
16740119
DOI:
10.1515/BC.2006.064
[Indexed for MEDLINE]

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