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Nat Cell Biol. 2006 Jun;8(6):640-2.

The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair.

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1
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.

Abstract

DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol kappa in mammalian NER.

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PMID:
16738703
DOI:
10.1038/ncb1417
[Indexed for MEDLINE]

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