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Semin Immunol. 2006 Jun;18(3):159-66.

Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.

Author information

1
Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA. dorite@umbi.umd.edu

Abstract

Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-I, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been determined to date, both in free form and bound to MHC class I or MHC class I-like molecules.

PMID:
16737824
PMCID:
PMC2519613
DOI:
10.1016/j.smim.2006.03.004
[Indexed for MEDLINE]
Free PMC Article

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