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Eur J Cancer. 2006 Jul;42(10):1407-14. Epub 2006 Jun 5.

Quality of life and persisting symptoms after oesophageal cancer surgery.

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Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery P9:03, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.


To assess quality of life (QoL) and symptoms after oesophageal cancer surgery, a prospective nationwide population-based study was conducted in 2001-2005, including most surgically treated oesophageal cancer patients in Sweden. Six months postoperatively patients responded to an EORTC quality of life core questionnaire (QLQ C-30) with an oesophageal-specific module (OES-18). Mean scores were calculated. Mann-Whitney test was used for group comparisons. Among 282 patients, QoL was considerably reduced compared to a reference general population (P<0.001), and functioning scales were similarly negatively affected; particularly role (P<0.001) and social (P<0.001) functions. Younger patients scored worse than older. No gender differences were found. Dominating general symptoms included fatigue, appetite loss, diarrhoea, and dyspnoea, each significantly more pronounced than the general population (P<0.001). Eating problems, cough, reflux, and oesophageal pain were common oesophageal-specific symptoms. Thus, patients who undergo oesophageal cancer resection suffer greatly from reduced QoL and several general and oesophageal-specific symptoms six months postoperatively.

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