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Eur J Pharmacol. 2006 Jul 1;540(1-3):200-1. Epub 2006 May 3.

Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.

Author information

1
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. robert.raffa@temple.edu

Abstract

Previous investigators have provided radioimmunological and immunocytochemical evidence for an enkephalinergic (opioid) system in Planaria and described naloxone-sensitive qualitative behavioral responses to kappa-opioid receptor agonists. We report the application of Schild-analysis to the antagonism of a selective kappa agonist (U-50,488H) by a selective kappa antagonist (nor-BNI) in a quantitative in vivo endpoint. The results provide further evidence of a kappa-opioid-like receptor in planarians.

PMID:
16737694
DOI:
10.1016/j.ejphar.2006.04.027
[Indexed for MEDLINE]

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