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Genome Biol. 2006;7(5):216. Epub 2006 May 30.

An overview of the serpin superfamily.

Author information

1
Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne VIC 3800, Australia.

Abstract

Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.

PMID:
16737556
PMCID:
PMC1779521
DOI:
10.1186/gb-2006-7-5-216
[Indexed for MEDLINE]
Free PMC Article

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