Achiral benzophenone ligand-rhodium complex with chiral diamine activator for high enantiocontrol in asymmetric transfer hydrogenation

Koichi Mikami; Kazuki Wakabayashi; Yukinori Yusa; Kohsuke Aikawa

doi:10.1039/b517585b

Achiral benzophenone ligand-rhodium complex with chiral diamine activator for high enantiocontrol in asymmetric transfer hydrogenation

Chem Commun (Camb). 2006 Jun 14:(22):2365-7. doi: 10.1039/b517585b. Epub 2006 May 3.

Authors

Koichi Mikami¹, Kazuki Wakabayashi, Yukinori Yusa, Kohsuke Aikawa

Affiliation

¹ Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, 152-8552, Japan. kmikami@o.cc.titech.ac.jp

PMID: 16733581
DOI: 10.1039/b517585b

Abstract

The chirality of an achiral benzophenone-based rhodium complex can be controlled by chiral diamines to afford significantly high enantioselectivity in the catalytic asymmetric transfer hydrogenation of ketones (up to 99% ee, 99% yield).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzophenones / chemistry*
Catalysis
Crystallography, X-Ray
Diamines / chemistry*
Hydrogenation
Ketones / chemical synthesis*
Ketones / chemistry
Ligands
Models, Molecular
Molecular Structure
Organometallic Compounds / chemistry*
Rhodium / chemistry*
Stereoisomerism

Substances

Benzophenones
Diamines
Ketones
Ligands
Organometallic Compounds
benzophenone
Rhodium